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KMID : 0361720070180040352
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Korean Journal of perinatology
2007 Volume.18 No. 4 p.352 ~ p.361
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Changes of Interleukin-6, C-reactive Protein, and Lipid Peroxide Levels in the Umbilical Venous Plasma of Preterm Birth with or without Chorioamnionitis
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Kim Yoon-Ha
Kim Cheol-Hong
Kim Ki-Min
Cho Moon-Kyoung
Kim Jong-Woon
Kim Jo-Heon
Nam Jong-Hee
Yang Sung-Yeul
Ahn Bong-Whan
Song Tae-Bok
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Abstract
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Objective: To investigate interleukin-6 (IL-6), C-reactive protein (CRP), and lipid peroxide levels in the umbilical venous plasma of preterm birth with or without histologic chorioamnionitis and to evaluate their roles of pathophysiology in preterm labor and perinatal outcome.
Methods: This cohort study included 66 cases of preterm delivery with preterm labor and intact membranes (PTL) (n=39) and preterm premature rupture of membranes (PPROM) (n=27). The umbilical venous blood samples were collected at time of delivery. IL-6, CRP, and lipid peroxide levels were measured by ELISA Kit, latex agglutination assay, and thiobarbituric acid reaction. Histologic chorioamnionitis was diagnosed in the presence of neutrophils infiltration into the subamnionic space.
Results: Histologic chorioamnionitis was significantly higher in PPROM (59.3%, 16/27) than in PTL (20.5%, 8/39). IL-6, CRP, and lipid peroxide levels in the umbilical venous plasma of histologic chorioamnionitis were significantly higher than those without histologic chorioamnionitis. IL-6, CRP, and lipid peroxide levels in the umbilical venous plasma of PTL with histologic chorioamnionitis were significantly higher than those of PTL without histologic chorioamnionitis. CRP levels in the umbilical venous plasma of PPROM with histologic chorioamnionitis were significantly higher than those of PPROM without histologic chorioamnionitis. Three suspected neonatal sepsis patients have increased IL-6 and lipid peroxide levels in the umbilical venous plasma compared with patients without neonatal sepsis. IL-6 levels in the umbilical venous plasma of histologic funisitis were significantly higher than those without funisitis.
Conclusion: Preterm birth with chorioamnionitis is associated with an increased levels of IL-6, CRP, and lipid peroxide in umbilical venous blood. Preterm birth with chorioamnionitis may have an effect on perinatal outcome.
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KEYWORD
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chorioamnionitis, umbilical venous plasma, interleukin-6 (IL-6)
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